An investigation is under way into how a 33-year-old man was found suffering critical injuries near Campbelltown.
Emergency services were called to Queenscliff Drive, Woodbine on Wednesday night after the injured man had approached a local resident for help.
It is not known how the man got there.
NSW Ambulance paramedics treated the man for multiple stab wounds, before taking him to hospital in a critical condition.
Officers from Campbelltown City Police Area Command were assisted by specialist forensic police with inquiries to locate a crime scene.
Detectives have established Strike Force Botumburra to investigative the circumstances surrounding the incident.
Anyone who may have information, CCTV or dashcam vision from the vicinity are urged to contact Campbelltown Police Station on 4620 1199 or Crime Stoppers on 1800 333 000.
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In a separate incident, a man who was the subject of a police pursuit has been arrested and is set to be charged with a number of offences.
Campbelltown Police Area Command officers had attempted to stop a stolen Holden Captiva, on Badgally Road, Claymore on Wednesday afternoon.
The Holden failed to stop, and a pursuit was initiated before being terminated due to safety concerns.
Shortly after, the Holden collided head-on with a Nissan Pathfinder on Gregory Hills Road, Gregory Hills.
Emergency services responded and police arrested the Holden driver, a 20-year-old man.
Both he and the Nissan driver, a woman aged in her 40s, were treated at the scene by NSW Ambulance paramedics.
The man was taken to Liverpool Hospital, under police guard, and the woman to Campbelltown Hospital. Both are in a stable condition.
An investigation is being held into the circumstances of the incident.
